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• Title: Phytochemical Analysis and in Vitro Evaluation of the Biological Activity Against Herpes Simplex Virus Type 1 (HSV-1) of Cedrus Libani A. Rich.
• Author : Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
• Release Date : January 01, 2008
• Genre: Life Sciences,Books,Science & Nature,
• Pages : * pages
• Size : 217 KB

Description

Abstract Cedrus libani are widely used as traditional medicine in Lebanon for treatment of different infection diseases. In the present study we reported the phytochemical composition analyzed by GC-MS of wood essential oil and cones and leaves ethanol extracts. The main components of wood essential oil were himachalol (22.50%), [beta]-himachalene (21.90%), and [alpha]-himachalene (10.50%). Leaves ethanol extract was characterized by a high content of germacrene D (29.40%). The same extract obtained from cones essentially contained [alpha]-pinene (51.0%) and [beta]-myrcene (13.0%). Moreover, we investigated extracts, essential oil, and identified compounds for their in vitro antiviral activities against herpes simplex virus type 1 (HSV-1). Cytotoxicity was evaluated by MTT assay in Vero cells. Cones and leaves ethanol extracts exhibited an interesting activity with [IC.sub.50] of 0.50 and 0.66 mg/ml, respectively, at non-cytotoxic concentration. A comparable activity was found when essential oil was tested ([IC.sub.50] of 0.44 mg/ml).

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